say-something-nice

say-something-nice t1_ix3l7xz wrote

Reply to comment by wintrmt3 in How does the body know which allele is dominant and which is recessive? by JannickL

Sorry my mistake guanine- cytosine

Higher GC content has been shown to affect polymerase efficiency in DNA elongation. It's not 100% understood why because it has been shown not to be due to the more stable bonds of GC and the better annealing which we exploit in primer design.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1463026/

https://www.pnas.org/doi/10.1073/pnas.1518976113

https://pubmed.ncbi.nlm.nih.gov/20203083/

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say-something-nice t1_iwztrwl wrote

Reply to How does the body know which allele is dominant and which is recessive? by JannickL

It's dependent on protein expression relative to the recessive allele. So will it be determined by factors controlling the rate of expression of that gene, It's transcription factors, the % of guanisine-Cytosine within the gene, it's structural availibility for transcription, It's epigentic modifications (DNA methylation) and many many more factors which control Gene expression.

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If one gene has more benenficial factors expression or if the other has as negative expression factors, the dominant gene's trait will be produced.

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