ambrosius-on-didymus
ambrosius-on-didymus t1_j8i86e0 wrote
Reply to comment by myusernamehere1 in A study found that CBD "exerted anti-cancer activity by reducing epithelial-mesenchymal transition and causing cell cycle arrest." by OregonTripleBeam
Very true in the sense that they are a great way to gain proof of concept for a novel drug early in development. But the vast majority of drugs that work well in vitro with cell cultures don’t work in vivo as a living creature (mouse, dog, human) is vastly more complex than a cell culture plate. Additionally, most of the popular cancer cell lines that are used in labs have been selected to be highly responsive to drugs to give research the greatest chance at success. I worked with CBD in a cancer drug development lab and it worked incredibly at killing cancer cells in vitro, but once you tried in an animal model, the effect size shrank dramatically and vanished more often than not.
ambrosius-on-didymus t1_j8i8qzm wrote
Reply to A study found that CBD "exerted anti-cancer activity by reducing epithelial-mesenchymal transition and causing cell cycle arrest." by OregonTripleBeam
I worked in a research lab before medical school that looked at this. Long story short, CBD (and actually CBD + THC more so) worked great at killing (or arresting the growth of) cancer cell lines in culture. Its effect was much smaller/did not give statistically significant results when you used primary tissue from actual tumors and/or used a mouse model.