Last-Initial3927
Last-Initial3927 t1_j2qcdve wrote
Can confirm, am Bot
Last-Initial3927 t1_iwt6xpu wrote
Reply to comment by phdoofus in Study finds age-related macular degeneration strongly associated with serious forms of cardiovascular disease, heart damage from heart failure and heart attacks by Living_And_Alive
Had heard a little about this before under the “lipotoxicity” hypothesis of MD where extracellular fat exerts stress on retinal cells and is “organised” by secreted lipoproteins. I believe it was a cycle of disrupted cell architecture (diminishing surface area) and increased local metabolic derangement.
Last-Initial3927 t1_iw7zp37 wrote
Reply to comment by AaronfromKY in A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice (Nov 2022) by basmwklz
I actually love shivering! It’s a specific neurological motor plan that involves radial muscle fiber firing. Super cool physiology if anyone is keen to read about it more.
Last-Initial3927 t1_iu8vpej wrote
Reply to comment by newdaynewnamenewyay in Newly discovered species of bacteria in the microbiome may be a culprit behind rheumatoid arthritis by geoxol
Scalp psoriasis I think…
Last-Initial3927 t1_isdbd21 wrote
Reply to comment by AutoModerator in Pain-Sensing Neurons Can Protect the Gut From Damage - A Harvard study has shown that pain neurons in mice shield the gut by stimulating nearby cells to produce protective mucus and maintain the gut barrier in response to microbes and inflammation. by swhelan_tn
Link to the original paper please
Last-Initial3927 t1_j4cq7mj wrote
Reply to comment by LizzieButtons in Alzheimer’s tied to cholesterol, abnormal nerve insulation by D-R-AZ
I think your question contains a great teaching point about genetics. I prefer to think about genetics as a repertoire like a toolbox that a carpenter brings to a job. What tools are used is somewhat dictated by what’s in the box but if he is say sawing a plank of wood then he’s not going to reach for the hammer. The cell is trying to make similar contextual decisions all of the time. Diet and exercise may dramatically alter both gene expression and the effect of a product secreted into a vastly different environment.