I am trying to understand the mechanism of this experiment. They dosed rats with a dopaminergic substance (amphetamines), and then cut off half of them (to cause depression), and then they measured the differences in serotonin in each group? This would suggest serotonin deficiency is symptomatic. Was there a control group measured without any amping at all? Which brings me to my next question, could dopamine then reverse the depression? Instead of serotonin?
Exact-Swan-3136 t1_iv6joaz wrote
Reply to BRAIN SEROTONIN RELEASE IS REDUCED IN PATIENTS WITH DEPRESSION: A [11C]Cimbi-36 PET STUDY WITH A D-AMPHETAMINE CHALLENGE. - Biological Psychiatry by chilladipa
I am trying to understand the mechanism of this experiment. They dosed rats with a dopaminergic substance (amphetamines), and then cut off half of them (to cause depression), and then they measured the differences in serotonin in each group? This would suggest serotonin deficiency is symptomatic. Was there a control group measured without any amping at all? Which brings me to my next question, could dopamine then reverse the depression? Instead of serotonin?