ELI-PGY5
ELI-PGY5 t1_iuh65hw wrote
Reply to comment by Ripheus-33 in Revealed: TE Lawrence felt ‘bitter shame’ over UK’s false promises of Arab self rule by Aboveground_Plush
I’m 80% sure the Turkish soldier thing is Lawrence’s homoerotic slash fiction, so don’t feel too bad for him. Controversial area, there is some decent scholarship on this issue.
ELI-PGY5 t1_iuh5pte wrote
Reply to comment by anunderdog in Revealed: TE Lawrence felt ‘bitter shame’ over UK’s false promises of Arab self rule by Aboveground_Plush
Left it on a train actually.
ELI-PGY5 t1_iu7lm1h wrote
Reply to comment by Daguvry in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
Yeah, I was think of a guy I saw recently with DKA, pH 6.9, not crisp but his cells were also not all dead.
ELI-PGY5 t1_iu5i898 wrote
Reply to comment by Existing_Thought5767 in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
That’s gibberish. pH of blood changes in specific disease states. Checking blood pH is a common, useful pathology test.
As for 0.2 = “cells destroyed very quickly” “body would literally not function” - you’re exaggerating. A drop of 0.2 (7.4 to 7.2) would not even count as a severe acidosis.
So I rate your comment 3.2% the right answer, not 100%.
ELI-PGY5 t1_iu5ei09 wrote
Reply to comment by Grogfoot in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
Sorry, it’s 2am and I misread. The guy I was responding to is too high not too low. Normal range for blood pH is .1 unit, I would disagree that pH varies by 0.2 in normal conditions, 7.2 to 7.4 is a pretty massive difference as you presumably know.
But that’s largely irrelevant to my point, which is that pH is not so stable that it can’t be used for diagnostic purposes. It’s just that it’s not used for the diagnostic purpose that the OP asked about, and the behaviour of tau proteins etc as noted in the reference doesn’t lead me to think that it is likely to be.
ELI-PGY5 t1_iu56p3o wrote
Reply to comment by NergalMP in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
- pH changes in bodily fluids are often clinically useful
- I don't really care about pH in CSF.
- I doubt it's a good test for Alzheimers, as we would presumably all be doing it if a $20 investigation could detect the condition. The linked article isn't very relevant to everyday clinical medicine.
ELI-PGY5 t1_iu4vi1s wrote
Reply to comment by Existing_Thought5767 in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
It’s not really the right answer. Because we test the pH of bodily fluids pretty regularly, and it’s clinically useful. Just not useful in CSF in standard practice, and it definitely not a standard test in Alzheimer’s.
ELI-PGY5 t1_iu4v6gs wrote
Reply to comment by DudoVene in Does the cerebral spinal fluid of people with Alzheimer's have a notably different pH from 'normal' people's? by wrhollin
The normal range for pH is 5 times that. And we see sick or sick-ish people outside that range pretty regularly. Pretty much everyone at my local hospital who gets blood drawn gets their pH checked.
But as to OPs question - my answer is no. We don’t have any simple tests for Alzheimer’s. MRI and PET provide decent info. But if pH on an LP was different, we’d suddenly have a simple, cheap-ish test for the condition.
pH isn’t a useful test on CSF in normal circumstances btw. We do care about pH in other fluids - pleural fluid, vaginal samples, blood etc.
ELI-PGY5 t1_iu4rj8p wrote
Reply to comment by ConstantConsumption in my dad wants to know if he should get a lawyer because he's losing money by brinkofwarz
He’s not suing any innocent guy who enjoys bat soup, he’ll be suing that one Chinese chap that fucked a pangolin.
ELI-PGY5 t1_iuh9avj wrote
Reply to comment by atn420 in Revealed: TE Lawrence felt ‘bitter shame’ over UK’s false promises of Arab self rule by Aboveground_Plush
…according to his self-aggrandising, partially fictitious accounts.